"I urge you to please notice when you are happy, and exclaim or murmur or think at some point, 'If this isn't nice, I don't know what is.'"
The actual advice here is technically a quote from Kurt Vonnegut's "good uncle" Alex, but Vonnegut was nice enough to pass it on at speeches and in A Man Without A Country. Though he was sometimes derided as too gloomy and cynical, Vonnegut's most resonant messages have always been hopeful in the face of almost-certain doom. And his best advice seems almost ridiculously simple: Give your own happiness a bit of brainspace.
"Many people need desperately to receive this message: 'I feel and think much as you do, care about many of the things you care about, although most people do not care about them. You are not alone.'"
In this response to his own question—"Why bother?"—in Timequake, his last novel, Vonnegut doesn't give a tired response about the urge to create; instead, he offers a pointed answer about how writing (and reading) make a lonesome world a little less so. The idea of connectedness—familial and otherwise—ran through much of his work, and it's nice to see that toward the end of his career, he hadn't lost the feeling that words can have an intimate, powerful impact.
The narrator delivering this line at the end of the first chapter of Deadeye Dick is alluding both to his father's befriending of Hitler and his own accidental murder of his neighbor, but like so many of these quotes, it resonates well beyond its context. The underlying philosophy of Vonnegut's work was always that existence is capricious and senseless, a difficult sentiment that he captured time and again with a bemused shake of the head. Indeed, the idea that life is just a series of small decisions that culminate into some sort of "destiny" is maddening, because you could easily ruin it all simply by making the wrong one. Ordering the fish, stepping onto a balcony, booking the wrong flight, getting married—a single misstep, and you're done for. At least when you're dead, you don't have to make any more damn choices. Wherever Vonnegut is, he's no doubt grateful for that.
If you want to read the complete list, please go on the wonderful original article at AVClub.com